Cagrilintide: Advanced Molecular Innovation for Metabolic Reset

At Molekula, we explore and celebrate the science behind molecules that transform human health. Cagrilintide is one such breakthrough—a next-generation, long-acting amylin analogue designed to support appetite regulation, metabolic balance, and weight optimization.

This acylated peptide acts as a non-selective agonist of amylin receptors (AMYR) and the calcitonin receptor (CTR), extending the therapeutic potential of native amylin with enhanced stability and efficacy. Unlike natural amylin, which is short-lived and prone to aggregation, cagrilintide is structurally optimized through lipidation and targeted amino acid substitutions (N14E, V17R, P37Y) to increase its half-life and solubility.

By activating key receptors in the brain’s homeostatic and hedonic pathways, cagrilintide promotes satiety, reduces food intake, and facilitates sustainable weight reduction. Clinical data show promising results—especially when paired with semaglutide in the synergistic combination known as CagriSema, which has demonstrated superior outcomes in both weight loss and glycemic control for individuals with obesity or type 2 diabetes.

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The information provided above is not intended to substitute medical advice, diagnosis, or treatment. Should you have any questions regarding a medical condition, seek the advice of your physician or a qualified healthcare provider.

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: “in glass”) are performed outside the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat and/or cure any medical condition, ailment or disease. Bodily introduction of any kind into animals or human is strictly prohibited by law.

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